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Chronic Respiratory Disease
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*NITRIC OXIDE
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Reviews

Exhaled nitric oxide in paediatric asthma

R Ratnawati

Faculty of Medicine, UNSW, Australia

P S Thomas

Faculty of Medicine, UNSW, Australia; Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Australia

Assessment of airway function is difficult in young children with asthma, and in addition, only reflects the status of the disease at the time of the measurement. Thus, there is increasing interest in monitoring airway inflammation in asthma, which may provide a longer term assessment of disease activity. Most methods of assessing asthmatic inflammation are invasive, and are not feasible in the paediatric population. This review discusses exhaled nitric oxide as a marker of asthmatic inflammation, and compares it with other recognized markers. Exhaled nitric oxide has the potential to become a noninvasive method of assessing asthma control in the paediatric population.

Key Words: airway inflammation • asthma control • exhaled nitric oxide • glucocorticosteroid

Chronic Respiratory Disease, Vol. 2, No. 3, 163-174 (2005)
DOI: 10.1191/1479972305cd73ra
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